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College Football odds and matchups, Week 5, 2025

Featured games16 games

Ranked matchups and prime-time games (kickoff 7 PM ET or later).

Friday, Sep 262 games

Fri, Sep 26, 7:00 PM ETFinalConference game· Scott Stadium
75°Rest FSU 6d · UVA 6dQB FSU Thomas Castellanos · UVA Chandler Morris

Closing · Spread FSU -7 · Total 59.5 · ML -270 / +220

Matchup
Fri, Sep 26, 9:00 PM ETFinalConference game· Mountain America Stadium
73°Rest TCU 6d · ASU 6d

Closing · Spread ASU -3 · Total 54.5 · ML +124 / -148

Matchup

Saturday, Sep 2714 games

Sat, Sep 27, 12:00 PM ETFinalConference game· Allegacy Federal Credit Union Stadium
71°Rest GT 7d · WAKE 16dQB GT Haynes King · WAKE Robby Ashford

Closing · Spread GT -13.5 · Total 53.5 · ML -550 / +410

Matchup
Sat, Sep 27, 12:00 PM ETFinalConference game· Gies Memorial Stadium
78°Rest USC 7d · ILL 7d

Closing · Spread USC -6.5 · Total 62.5 · ML -250 / +205

Matchup
Sat, Sep 27, 12:00 PM ETFinal· Donald W. Reynolds Razorback Stadium
73°Rest ND 7d · ARK 7d

Closing · Spread ND -5.5 · Total 64.5 · ML -218 / +180

Matchup
Sat, Sep 27, 12:45 PM ETFinal· FirstBank Stadium
76°Rest USU 7d · VAN 7dQB USU Bryson Barnes · VAN Diego Pavia

Closing · Spread VAN -23.5 · Total 57.5 · ML +1100 / -2100

Matchup
Sat, Sep 27, 3:30 PM ETFinalConference game· Husky Stadium
62°Rest OSU 14d · WASH 7dQB OSU Julian Sayin · WASH Demond Williams Jr.

Closing · Spread OSU -9.5 · Total 52.5 · ML -375 / +295

Matchup
Sat, Sep 27, 3:30 PM ETFinalConference game· Vaught-Hemingway Stadium
55°Rest LSU 7d · MISS 7dQB LSU Garrett Nussmeier · MISS Trinidad Chambliss

Closing · Spread MISS -2.5 · Total 57.5 · ML +120 / -142

Matchup
Sat, Sep 27, 3:30 PM ETFinalConference game· Kyle Field
87°Rest AUB 7d · TA&M 14d

Closing · Spread TA&M -6.5 · Total 51.5 · ML +195 / -238

Matchup
Sat, Sep 27, 3:30 PM ETFinalConference game· Kinnick Stadium
84° · 11 mph windRest IU 7d · IOWA 8dQB IU Fernando Mendoza · IOWA Mark Gronowski

Closing · Spread IU -9.5 · Total 47.5 · ML -340 / +270

Matchup
Sat, Sep 27, 4:15 PM ETFinalConference game· Davis Wade Stadium
82°Rest TENN 7d · MSST 7dQB TENN Joey Aguilar · MSST Blake Shapen

Closing · Spread TENN -7.5 · Total 63.5 · ML -290 / +235

Matchup
Sat, Sep 27, 7:00 PM ETFinalConference game· Jack Trice Stadium
75°Rest ARIZ 15d · ISU 14d

Closing · Spread ISU -4 · Total 48.5 · ML +150 / -180

Matchup
Sat, Sep 27, 7:30 PM ETFinalConference game· Beaver Stadium
79°Rest ORE 7d · PSU 14dQB ORE Dante Moore · PSU Drew Allar

Closing · Spread PSU -3.5 · Total 53.5 · ML +150 / -180

Matchup
Sat, Sep 27, 7:30 PM ETFinalConference game· Sanford Stadium
62°Rest ALA 14d · UGA 14dQB ALA Ty Simpson · UGA Gunner Stockton

Closing · Spread UGA -2.5 · Total 53.5 · ML +120 / -142

Matchup
Sat, Sep 27, 7:30 PM ETFinal· Memorial Stadium
77°Rest MASS 14d · MIZ 7dQB MASS Grant Jordan · MIZ Beau Pribula

Closing · Spread MIZ -44.5 · Total 57.5

Matchup
Sat, Sep 27, 10:15 PM ETFinalConference game· Folsom Field
61°Rest BYU 7d · COLO 7dQB BYU Bear Bachmeier · COLO Kaidon Salter

Closing · Spread BYU -6.5 · Total 48.5 · ML -250 / +205

Matchup

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Kickoffs, lines and conditions for every game. 53 of 53 final.

Lines are the market's, from the sportsbooks we track; weather is the forecast for kickoff. The model's picks for these games are under Predictions. For information only, not betting advice. 21+ only. Gambling problem? Call or text 1-800-GAMBLER.