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College Football odds and matchups, Week 4, 2025

Featured games16 games

Ranked matchups and prime-time games (kickoff 7 PM ET or later).

Saturday, Sep 2016 games

Sat, Sep 20, 12:00 PM ETFinalConference game· Rice-Eccles Stadium
72°Rest TTU 7d · UTAH 7dQB TTU Behren Morton · UTAH Devon Dampier

Closing · Spread UTAH -3.5 · Total 58.5 · ML +145 / -175

Matchup
Sat, Sep 20, 12:45 PM ETFinal· Neyland Stadium
80°Rest UAB 7d · TENN 7d

Closing · Spread TENN -39.5 · Total 69.5

Matchup
Sat, Sep 20, 3:00 PM ETFinal· Autzen Stadium
69°Rest ORST 7d · ORE 7dQB ORST Maalik Murphy · ORE Dante Moore

Closing · Spread ORE -33.5 · Total 58.5

Matchup
Sat, Sep 20, 3:30 PM ETFinal· Doak Campbell Stadium
93°Rest KENT 7d · FSU 14dQB KENT Dru Deshields · FSU Thomas Castellanos

Closing · Spread FSU -44.5 · Total 56.5

Matchup
Sat, Sep 20, 3:30 PM ETFinalConference game· Memorial Stadium (Norman, OK)
88°Rest AUB 7d · OU 7d

Closing · Spread OU -6.5 · Total 47.5 · ML +200 / -245

Matchup
Sat, Sep 20, 3:30 PM ETFinal· Vaught-Hemingway Stadium
59° · 20 mph windRest TULN 7d · MISS 7dQB TULN Jake Retzlaff · MISS Trinidad Chambliss

Closing · Spread MISS -12.5 · Total 61.5 · ML +340 / -440

Matchup
Sat, Sep 20, 3:30 PM ETFinalConference game· Memorial Stadium (Lincoln, NE)
72°Rest MICH 7d · NEB 7dQB MICH Bryce Underwood · NEB Dylan Raiola

Closing · Spread MICH -1.5 · Total 47.5 · ML -118 / -102

Matchup
Sat, Sep 20, 3:30 PM ETFinal· Notre Dame Stadium
58° · 13 mph windRest PUR 7d · ND 7dQB PUR Ryan Browne · ND C.J. Carr

Closing · Spread ND -24.5 · Total 51.5 · ML +1200 / -2400

Matchup
Sat, Sep 20, 5:05 PM ETFinal· Bobby Dodd Stadium
87°Rest TEM 7d · GT 7dQB TEM Evan Simon · GT Haynes King

Closing · Spread GT -24.5 · Total 52.5 · ML +1200 / -2400

Matchup
Sat, Sep 20, 7:00 PM ETFinalConference game· Memorial Stadium
81°Rest SC 7d · MIZ 7dQB SC Lanorris Sellers · MIZ Beau Pribula

Closing · Spread MIZ -10 · Total 48.5 · ML +280 / -355

Matchup
Sat, Sep 20, 7:30 PM ETFinal· Hard Rock Stadium
79°Rest FLA 7d · MIA 7dQB FLA D.J. Lagway · MIA Carson Beck

Closing · Spread MIA -8.5 · Total 51.5 · ML +270 / -340

Matchup
Sat, Sep 20, 7:30 PM ETFinalConference game· Memorial Stadium (Bloomington, IN)
79°Rest ILL 7d · IU 8dQB ILL Luke Altmyer · IU Fernando Mendoza

Closing · Spread IU -7 · Total 51.5 · ML +215 / -265

Matchup
Sat, Sep 20, 7:30 PM ETFinal· FirstBank Stadium
85°Rest GAST 7d · VAN 7dQB GAST TJ Finley · VAN Diego Pavia

Closing · Spread VAN -27.5 · Total 53.5 · ML +1700 / -4500

Matchup
Sat, Sep 20, 7:45 PM ETFinal· Tiger Stadium (LA)
90°Rest SELA 21d · LSU 7dQB SELA Carson Camp · LSU Garrett Nussmeier

Closing · Spread LSU -48.5 · Total 60.5

Matchup
Sat, Sep 20, 8:00 PM ETFinal· DKR-Texas Memorial Stadium
90°Rest SHSU 14d · TEX 7dQB SHSU Mabrey Mettauer · TEX Arch Manning

Closing · Spread TEX -39.5 · Total 51.5

Matchup
Sat, Sep 20, 11:00 PM ETFinalConference game· Los Angeles Memorial Coliseum
70°Rest MSU 7d · USC 7d

Closing · Spread USC -18.5 · Total 55.5 · ML +625 / -950

Matchup

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Kickoffs, lines and conditions for every game. 62 of 62 final.

Lines are the market's, from the sportsbooks we track; weather is the forecast for kickoff. The model's picks for these games are under Predictions. For information only, not betting advice. 21+ only. Gambling problem? Call or text 1-800-GAMBLER.