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College Football odds and matchups, Week 2, 2025

Featured games16 games

Ranked matchups and prime-time games (kickoff 7 PM ET or later).

Saturday, Sep 616 games

Sat, Sep 6, 12:00 PM ETFinal· Beaver Stadium
65°Rest FIU 8d · PSU 7dQB FIU Keyone Jenkins · PSU Drew Allar

Closing · Spread PSU -41.5 · Total 53.5

Matchup
Sat, Sep 6, 12:00 PM ETFinal· DKR-Texas Memorial Stadium
83°Rest SJSU 8d · TEX 7d

Closing · Spread TEX -36.5 · Total 52.5

Matchup
Sat, Sep 6, 12:00 PM ETFinal· Wallace Wade Stadium
86°Rest ILL 8d · DUKE 9dQB ILL Luke Altmyer · DUKE Darian Mensah

Closing · Spread ILL -2.5 · Total 49.5 · ML -135 / +115

Matchup
Sat, Sep 6, 12:00 PM ETFinal· Doak Campbell Stadium
91°Rest TAMC 7d · FSU 7dQB TAMC Eric Rodriguez · FSU Thomas Castellanos

Closing · Spread FSU -43.5 · Total 56.5

Matchup
Sat, Sep 6, 12:00 PM ETFinal· Jack Trice Stadium
58°Rest IOWA 7d · ISU 7dQB IOWA Mark Gronowski · ISU Rocco Becht

Closing · Spread ISU -1.5

Matchup
Sat, Sep 6, 12:00 PM ETFinal· Gerald J. Ford Stadium
66°Rest BAY 8d · SMU 7dQB BAY Sawyer Robertson · SMU Kevin Jennings

Closing · Spread SMU -2.5 · Total 65.5 · ML +130 / -150

Matchup
Sat, Sep 6, 2:28 PM ETFinal· Sanford Stadium
81°Rest APSU 7d · UGA 7dQB APSU Chris Parson · UGA Gunner Stockton

Closing · Spread UGA -46.5 · Total 56.5

Matchup
Sat, Sep 6, 3:30 PM ETFinal· Ohio Stadium
69°Rest GRAM 7d · OSU 7dQB GRAM Myles Crawley · OSU Julian Sayin

Closing · Spread OSU -51.5 · Total 64.5

Matchup
Sat, Sep 6, 3:30 PM ETFinal· Autzen Stadium
71°Rest OKST 9d · ORE 7dQB OKST Zane Flores · ORE Dante Moore

Closing · Spread ORE -28.5 · Total 55.5

Matchup
Sat, Sep 6, 3:30 PM ETFinal· Memorial Stadium (Clemson, SC)
74°Rest TROY 7d · CLEM 7dQB TROY Will Crowder · CLEM Cade Klubnik

Closing · Spread CLEM -29.5 · Total 51.5

Matchup
Sat, Sep 6, 4:15 PM ETFinal· Ben Hill Griffin Stadium
80°Rest USF 9d · FLA 7dQB USF Byrum Brown · FLA Tramell Jones Jr.

Closing · Spread FLA -18.5 · Total 58.5 · ML +600 / -1000

Matchup
Sat, Sep 6, 7:00 PM ETFinal· Hard Rock Stadium
82°Rest BCU 8d · MIA 6dQB BCU Timmy McClain · MIA Carson Beck

Closing · Spread MIA -54.5 · Total 64.5

Matchup
Sat, Sep 6, 7:00 PM ETFinal· Williams-Brice Stadium
79°Rest SCST 7d · SC 6dQB SCST Andre Washington · SC Lanorris Sellers

Closing · Spread SC -42.5 · Total 54.5

Matchup
Sat, Sep 6, 7:30 PM ETFinal· Tiger Stadium (LA)
89°Rest LT 7d · LSU 7dQB LT Trey Kukuk · LSU Garrett Nussmeier

Closing · Spread LSU -36.5 · Total 49.5

Matchup
Sat, Sep 6, 7:30 PM ETFinal· Davis Wade Stadium
74°Rest ASU 7d · MSST 7d

Closing · Spread ASU -5.5 · Total 58.5 · ML -200 / +170

Matchup
Sat, Sep 6, 7:30 PM ETFinal· Memorial Stadium (Norman, OK)
72°Rest MICH 7d · OU 7dQB MICH Bryce Underwood · OU John Mateer

Closing · Spread OU -3 · Total 47.5 · ML +124 / -148

Matchup

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Kickoffs, lines and conditions for every game. 83 of 83 final.

Lines are the market's, from the sportsbooks we track; weather is the forecast for kickoff. The model's picks for these games are under Predictions. For information only, not betting advice. 21+ only. Gambling problem? Call or text 1-800-GAMBLER.